Online Learning Models for Content Popularity Prediction In Wireless Edge Caching

Caching popular contents in advance is an important technique to achieve the low latency requirement and to reduce the backhaul costs in future wireless communications. Considering a network with base stations distributed as a Poisson point process (PPP), optimal content placement caching probabilities are derived for known popularity profile, which is unknown in practice. In this paper, online prediction (OP) and online learning (OL) methods are presented based on popularity prediction model (PPM) and Grassmannian prediction model (GPM), to predict the content profile for future time slots for time-varying popularities. In OP, the problem of finding the coefficients is modeled as a constrained non-negative least squares (NNLS) problem which is solved with a modified NNLS algorithm. In addition, these two models are compared with log-request prediction model (RPM), information prediction model (IPM) and average success probability (ASP) based model. Next, in OL methods for the time-varying case, the cumulative mean squared error (MSE) is minimized and the MSE regret is analyzed for each of the models. Moreover, for quasi-time varying case where the popularity changes block-wise, KWIK (know what it knows) learning method is modified for these models to improve the prediction MSE and ASP performance. Simulation results show that for OP, PPM and GPM provides the best ASP among these models, concluding that minimum mean squared error based models do not necessarily result in optimal ASP. OL based models yield approximately similar ASP and MSE, while for quasi-time varying case, KWIK methods provide better performance, which has been verified with MovieLens dataset.Comment: 9 figure, 29 page

Economic losses occurring due to brucellosis in Indian livestock populations.

Brucellosis is a serious public health issue in India. Estimation of economic losses occurring due to brucellosis is required to help formulate prevention and control strategies, but has not been done in India. We estimated economic losses due to brucellosis by sourcing prevalence data from epidemiological surveys conducted in India. Data for livestock populations were obtained from official records. Probability distributions were used for many of the input parameters to account for uncertainty and variability. The analysis revealed that brucellosis in livestock is responsible for a median loss of US $3.4 billion (5th–95th percentile 2.8–4.2 billion). The disease in cattle and buffalo accounted for 95.6$ 6.8 per cattle, US$18.2 per buffalo, US$ 0.7 per sheep, US$0.5 per goat and US$ 0.6 per pig. These losses are additional to the economic and social consequences of the disease in humans. The results suggest that the disease causes significant economic losses in the country and should be controlled on a priority basis. Keywords: bovine brucellosis; ovine brucellosis; porcine brucellosis; economic loss; India; developing countries; zoonoses; partial budgeting Highlights • This is the first systematic analysis of the economic losses occurring due to brucellosis in livestock populations in India. • The analysis revealed that brucellosis in livestock is responsible for a median loss of US $ 3.4 billion (5th–95th percentile 2.8–4.2 billion). • There is urgent need to formulate intervention policies for prevention and control of this disease in India

A Review on Multi Approaches for Impurity Isolation and its Characterization

International Conference on Harmonization (ICH) has formulated different guideline regarding the control of impurities. In this review,  the impurity sources, classification, isolation, detection and characterization methods are described. The some impurities are unavoidable and will be present in trace amounts hence ICH guidelines frame the different policies and establish the specification limits, isolation and characterization is necessary for evaluation and control of impurities. The other regulatory bodies and drug development authorities look up to these guidelines for launching a quality drug into the market. Validation of analytical process for impurity identification is performed to establish the impurity profile of any drug substance. Hence the major focus of this review article is on isolation and characterization of impurities using various technics, sources and classifications, establishment of impurity profile and analytical approaches to establish its profile. We also could apply the QbD to providing statistical documentary evidences. Keywords: Impurity profile, Impurities isolation methods, chromatographic separation, Impurity Characterization, ICH, QbD

A framework for the selection of the right nuclear power plant

Civil nuclear reactors are used for the production of electrical energy. In the nuclear industry vendors propose several nuclear reactor designs with a size from 35–45 MWe up to 1600–1700 MWe. The choice of the right design is a multidimensional problem since a utility has to include not only financial factors as levelised cost of electricity (LCOE) and internal rate of return (IRR), but also the so called “external factors” like the required spinning reserve, the impact on local industry and the social acceptability. Therefore it is necessary to balance advantages and disadvantages of each design during the entire life cycle of the plant, usually 40–60 years. In the scientific literature there are several techniques for solving this multidimensional problem. Unfortunately it does not seem possible to apply these methodologies as they are, since the problem is too complex and it is difficult to provide consistent and trustworthy expert judgments. This paper fills the gap, proposing a two-step framework to choosing the best nuclear reactor at the pre-feasibility study phase. The paper shows in detail how to use the methodology, comparing the choice of a small-medium reactor (SMR) with a large reactor (LR), characterised, according to the International Atomic Energy Agency (2006), by an electrical output respectively lower and higher than 700 MWe

Ethnobotanical plants used in health care and traditional practices by local inhabitants (Gujjars) of Rajaji Tiger Reserve, Uttarakhand, India

91-105The present investigation aims to identify the ethnobotanical plants collected by local inhabitants (Gujjars) of Rajaji tiger reserve for medical purposes. Data was collected from 2015-2018 about the uses to ethnomedicinal plants through personal interview, group discussion and questionnaire with predetermined informants. During the period, a total of 60 ethnomedicinal plants were collected in which majority of the plants were wild which was used by the local community in the treatment of different problems. At the time of the survey, demographic characteristics of the Gujjars and other related data was also noted. The collected data was also analysed through use value (UV), informants census factors (Fic), fidelity level (FL) etc. Various ethnomedicinal plants species which we have collected from the study area have not been explored from the other areas of the Western Himalaya. These ethnomedicnal plant species could be used for phytochemical, antimicrobial and pharmacological aspects in future

Response of Hirayama disease to surgical intervention: case report

Hirayama disease also known as monomelic amyotrophy, primarily involves distal upper limb extremities.It differs from the known types of motor neuron diseases because of its nonprogressive behavior and pathologic findings of focal ischemic changes in the anterior horn of the lower cervical cord. We present a young male with Hirayama disease who had a left upper extremity involvement which was progressive in nature. He didn’t respond with initial treatment of cervical collar. Consequently surgical intervention improves muscle weakness and decrease the neurological deficit. 

A retrospective study of admission trends of koalas to a rehabilitation facility over 30 years

To identify threats to the survival of koalas (Phascolarctos cinereus) in coastal New South Wales, Australia, we compared 3,781 admission records of koalas, admitted between 1 January 1975 and 31 December 2004 to a koala rehabilitation facility on the midnorthern coast of New South Wales, against local wild population demographics, with the use of multinomial logistic regression and chi-square analyses. Trauma, the most frequent reason for admission, affected young and male animals more frequently than other groups. Seasonal differences in the probability of males presenting as trauma cases suggest behavioral factors as an important risk factor for this group. An increasing probability of koalas presenting as a result of motor vehicle accident since 1985 strongly supports the enhanced action of local authorities to pursue traffic-calming strategies if urban koala populations are to be maintained in this area. Koalas with clinical signs of chlamydiosis made up the second most frequent admission group, and these animals were more likely to be aged. This study highlights the potential usefulness of wildlife rehabilitation centers in detailing threats to local wildlife populations, provided record keeping is efficient and focused, and the role of such studies in providing evidence for focusing threat-mitigation efforts. Continual community engagement by koala researchers is important to ensure that maximum benefit is obtained from activities of special interest groups. Keywords: Koala, Phascolarctos cinereus, New South Wales, threats, wildlife rehabilitationARC Linkage Grant LP0560572

Environmental Survival of Mycobacterium avium subsp. paratuberculosis in Different Climatic Zones of Eastern Australia.

The duration of survival of both the S and C strains of Mycobacterium avium subsp. paratuberculosis in feces was quantified in contrasting climatic zones of New South Wales, Australia, and detailed environmental temperature data were collected. Known concentrations of S and C strains in feces placed on soil in polystyrene boxes were exposed to the environment with or without the provision of shade (70%) at Bathurst, Armidale, Condobolin, and Broken Hill, and subsamples taken every 2 weeks were cultured for the presence of M. avium subsp. paratuberculosis. The duration of survival ranged from a minimum of 1 week to a maximum of 16 weeks, and the provision of 70% shade was the most important factor in extending the survival time. The hazard of death for exposed compared to shaded samples was 20 and 9 times higher for the S and C strains, respectively. Site did not affect the survival of the C strain, but for the S strain, the hazard of death was 2.3 times higher at the two arid zone sites (Broken Hill and Condobolin) than at the two temperate zone sites (Bathurst and Armidale). Temperature measurements revealed maximum temperatures exceeding 60°C and large daily temperature ranges at the soil surface, particularly in exposed boxes.This work was supported by the NSW sheep industry through the NSW Ovine Johne's Disease Industry Fund and the NSW Rural Assistance Authority

Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Treatment With Targeted Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Clinical Practice Guideline Update

Purpose In response to advances in the field, the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) recently updated their recommendations for molecular testing for the selection of patients with lung cancer for treatment with targeted tyrosine kinase inhibitors. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The molecular testing guideline was reviewed for developmental rigor by methodologists. Then an ASCO Expert Panel reviewed the content and the recommendations. Results The ASCO Expert Panel determined that the recommendations from the CAP/IASLC/AMP molecular testing guideline are clear, thorough, and based upon the most relevant scientific evidence. ASCO endorsed the guideline with minor modifications. Recommendations This update clarifies that any sample with adequate cellularity and preservation may be tested and that analytical methods must be able to detect mutation in a sample with as little as 20% cancer cells. It strongly recommends against evaluating epidermal growth factor receptor (EGFR) expression by immunohistochemistry for selection of patients for EGFR-targeted therapy. New for 2018 are recommendations for stand-alone ROS1 testing with additional confirmation testing in all patients with advanced lung adenocarcinoma, and RET, ERBB2 (HER2), KRAS, and MET testing as part of larger panels. ASCO also recommends stand-alone BRAF testing in patients with advanced lung adenocarcinoma. Recommendations are also provided for testing methods for lung cancers that have a nonadenocarcinoma non-small-cell component, for patients with targetable mutations who have relapsed on targeted therapy, and for testing the presence of circulating cell-free DNA. Additional information is available at www.asco.org/thoracic-cancer-guidelines and www.asco.org/guidelineswiki